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PART 3: What Happens When You Take Too Much Tylenol (The Liver Connection) Time to talk about the organ that processes Tylenol - and why overdosing can be deadly. YOUR LIVER'S TWO-PATHWAY SYSTEM: Pathway 1 (90% of Tylenol): Enzymes called sulfotransferase and UDP-glucuronosyltransferase break down most Tylenol into harmless metabolites that get filtered out through your kidneys into urine. No problem here. Pathway 2 (10% of Tylenol): Cytochrome P450 enzymes create a toxic substance called NAPQI.
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