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Harvard Stem Cell Institute - First 5 years — Harvard Gazette
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Cancer cell lines are the workhorses of cancer research, but scientists often struggle to reproduce others' cell line-based results. A new study from the Golub laboratory at the Broad Institute credits evolution as a key culprit behind this replication problem. Here, Uri Ben-David and Todd Golub discuss their efforts to measure how much cancer cell lines evolve in the laboratory, how that evolution affects cell lines' responses to drugs, and what cancer researchers should do to adapt their appro
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