Down Syndrome Awareness Month - Day 9 Let’s talk about TWINS! As you might guess, twins with Down syndrome are pretty rare. In some families with fraternal twins, only one twin has Down syndrome. Other families have identical twins where both have Down syndrome. Then there’s Charlie and Milo — a very unique, extremely rare set of fraternal twins who both have Down syndrome. I haven’t even been able to find reliable statistics about how rare this is. 😳✨ It took us a while to realize we had hit t