As awareness about dementia continues to grow worldwide, a spate of online courses aims to help both health professionals and the general public understand Alzheimer’s and related diseases. Below is a ...

These parkin knockout (KO) mice were generated by creating a germline disruption in the parkin gene within exon 3 leading to a truncated transcript coding for the first 95 amino acids of mouse parkin ...

Summary Two lines of transgenic mice that overexpress PSEN1 with the M146V mutation were developed simulataneously (line 8.2 and line 8.9) (Duff et al., 1996). Both lines have been crossed to Tg2576 ...

TASTPM is a double transgenic mouse model of Alzheimer’s disease carrying two mutations associated with early onset disease: the Swedish mutation in APP and the M146V mutation in PSEN1. The double ...

Notice of early expiration of PAR-24-213 NINDS Alzheimer’s Disease-Related Dementias (ADRD) Advanced Postdoctoral Career Transition Award (K99/R00 Independent Clinical Trial Not Allowed). The last ...

This approach uses mesenchymal stem cells isolated from a patient’s own fat tissue to treat neurodegenerative diseases. The stem cells are supposed to assist in repair of damaged tissue and ...

As the strongest risk factor for Alzheimer’s disease, ApoE4 has a bad reputation, and rightly so. Yet shade thrown on ApoE4 may be obscuring the inconvenient truth that ApoE3 isn’t so innocent, either ...

What makes synapses disappear with age? In the January 21 Nature, scientists led by Tony Wyss-Coray at Stanford University School of Medicine, California, report that sluggish turnover of synaptic ...

The center accepts tissue donations from participants in longitudinal and/or clinical medial studies run by its doctors, as well as some other donors. Phenotypes collected include Alzheimer’s disease, ...

The following are selected lists of antibodies against microglial proteins that are available through the Monoclonal Antibody Core Facility at Helmholtz Munich.

R47H is a rare variant in TREM2 that triples the risk of Alzheimer’s disease in heterozygous carriers of this variant. In order to study the effects of R47H TREM2 in the context of amyloidosis, Trem2 ...

Sensory Stimulation Systems, and GENUS, refer to a noninvasive procedure, i.e., a "digital therapeutic," being developed by Cognito Therapeutics. The company developed a wearable GammaSense ...