ascopubs.org

Plasma levels of SN-38 after co-administration of gefitinib and oral irinotecan in young and old mice

40 mg/kg 151.1 (3.0) 1997.4 (37.6) 362.4 (7.6) 1154.1 (25.2) 20 mg/kg 156.1 (3.8) 602.6 (9.5) 220.0 (8.1) 645.3 (20.9) 10 mg/kg 61.6 (0.3) 274.0 (5.0) 95.2 (1.3) 266.5 (8.5) All doses given by oral ...

Why do scientists use mice for experiments and how do they mirror human biology?

Mice are indispensable in biomedical research due to their genetic and anatomical similarities to humans, short lifespans, ...
ascopubs.org

Synergistic antitumor activity of the SN-38-incorporating polymeric micelles NK012 with S-1.

Inhibition of triple-negative breast cancer (TNBC) and breast cancer stem cells (bCSC) by caffeic acid phenethyl ester (CAPE). Background: The combination therapy of CPT-11, a prodrug of SN-38, with S ...
GEN

Diabetes, Metabolic Syndrome in Mice Treated Using Novel Compound Class

Researchers at Washington University School of Medicine in St. Louis have developed a new class of compounds that can improve multiple aspects of metabolic syndrome. The compounds act as modulators of ...