Nature

The bovine papillomavirus oncoprotein E5 retains MHC class I molecules in the Golgi apparatus and prevents their transport to the cell surface

During papillomavirus infection, the E5 protein localizes in the cell Golgi apparatus and other endomembrane compartments. Cells transformed by E5 do not express major histocompatibility class I ...
Nature

The E5 protein of BPV-4 interacts with the heavy chain of MHC class I and irreversibly retains the MHC complex in the Golgi apparatus

The downregulation of MHC class I by BPV E5 takes place at several levels: transcription of the HC, degradation of the HC and transport of the MHC complex to the cell surface (Ashrafi et al., 2002; ...