Immune cells must learn not to attack the body itself. A team of researchers has discovered a previously unknown mechanism behind this: other immune cells, the B cells, contribute to the 'training' of ...

A study by NIH researchers reveals that children with mitochondrial disorders have impaired antibody responses to viral infections due to altered B cell function. These patients experience weaker ...

Casitas B-lineage lymphoma-b (CBLB) is an E3 ubiquitin–protein ligase that functions as an intracellular checkpoint and master negative regulator of T‑cell and natural killer (NK) cell activation, ...