The cellular and molecular mechanisms that lend AJs this versatility are not well understood, but the actin motor, myosin II, has previously been implicated in AJ assembly and function 1. Now, on page ...

Over the last several years the identification and functional characterization of the motor proteins actin and myosin in the nucleus has initiated a change in the view of nuclear processes. It is now ...

Point mutations in vascular smooth muscle α-actin (SM α-actin), encoded by the gene ACTA2, are the most prevalent cause of familial thoracic aortic aneurysms and dissections (TAAD). Here, we provide ...

This is a preview. Log in through your library . Abstract The organization of actin in mouse neuroblastoma and chicken dorsal root ganglion (DRG) nerve cells was investigated by means of a variety of ...

ORLANDO -- A selective cardiac myosin activator showed potential ties to improved left ventricular (LV) function and symptoms in some heart failure patients with reduced ejection fraction, according ...

Skeletal and heart muscles contract and relax upon sliding of parallel filaments of the proteins myosin and actin. Nebulin, another long slender protein, which is present only in skeletal muscle, ...

Scientists at the Max Delbrück Center for Molecular Medicine (MDC) in the Helmholtz Association say they have developed a mouse model that enables them to look inside a working muscle and identify the ...

Some cells, such as immune cells, are highly mobile—they constantly remodel their shape, migrate toward a wound that needs to be closed or chase down bacteria in the bloodstream. This mobility is ...