Gene therapy using cDNA driven by an exogenous promoter is not suited for genetic disorders that require intrinsic expression of a transgene, such as hyperimmunoglobulin (Ig)M syndrome (HIGM), which ...
Gene targeting, the use of homologous recombination in mouse embryonic stem (ES) cells to modify mouse genes precisely 1,2,3,4,5, allows researchers to create virtually any desired modification in the ...
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