Ibuprofen might have advantages over indomethacin, when used to effectuate closure of a neonate's patent ductus arteriosus (PDA). Several previous studies indicate that platelet plug formation is ...

Megakaryocytes, which are derived from hematopoietic stem cell precursors in bone marrow, form and release platelets; these circulate in the blood for 8 to 10 days before they are removed by hepatic ...

THE term primary or "spontaneous" hemostasis refers to a complex series of biologic events occurring in immediate response to blood-vessel severance or injury. Although damaged or cut blood vessels ...

Uremic bleeding syndrome is a recognized consequence of renal failure and can result in clinically significant sequelae. Although the pathophysiology of the condition has yet to be fully elucidated, ...

PHILADELPHIA — Blood platelets shore up open wounds and help cuts heal, but they can also cause heart attacks and strokes when a congealed ball of platelets known as a thrombus breaks free from a site ...

HEMORRHAGE is a frequent and often major complication in patients with acute leukemia. In addition to thrombocytopenia and its resulting coagulation defects disturbances of the hemostatic mechanism ...

In 2010, more than 25 million prescriptions for selective serotonin reuptake inhibitor (SSRI) antidepressants were dispensed in Canada (Josiane Gaudet, Brogan IMS, Kirkland, Quebec: personal ...

It has been known for many decades that uremic bleeding and platelet dysfunction put patients at increased risk of general bleeding. The exact mechanism by which the risk is increased remains largely ...