Patriots-Ravens was picked as the flex in a week that has a number of other big games. Significant matchups around the league that week also include the Packers at the Bears, Jaguars at the Broncos, and Buccaneers at the Panthers (there's also a Rams-Seahawks matchup, but that is already in primetime as Thursday Night Football).

Week 13 AFC Defensive Player of the Week, and standout Bills cornerback Christian Benford appears to be on the wrong side of questionable due to a toe injury.

The Patriots, who can clinch the AFC East by completing the sweep of the Bills, are 1.5-point underdogs against Buffalo. Coach Mike Vrabel undoubtedly will find a way to use that to poke and prod his players — even if the Bills had nothing to do with the setting of the line.

The New England Patriots made the hire of the offseason by bringing back franchise great Mike Vrabel as head coach.

The Bills (9-4) need to beat the Patriots (11-2) on Sunday to retain hopes for a sixth straight division title.