JSTOR Daily

Temporal regulation of nicotinic acetylcholine receptor subunits supports central cholinergic synapse development in Drosophila

Proceedings of the National Academy of Sciences of the United States of America, Vol. 118, No. 23 (June 8, 2021), pp. 1-12 (12 pages) The construction and maturation of the postsynaptic apparatus are ...
Nature

Rat neuronal nicotinic acetylcholine receptors containing α7 subunit: pharmacological properties of ligand binding and function

To compare pharmacological properties of heterologously expressed homomeric α7 nicotinic acetylcholine receptors (α7 nAChRs) with those of native nAChRs containing α7 subunit (α7 * nAChRs) in rat ...
Nature

Nicotinic acetylcholine receptor α7 subunits with a C2 cytoplasmic loop yellow fluorescent protein insertion form functional receptors

Several nicotinic acetylcholine receptor (nAChR) subunits have been engineered as fluorescent protein (FP) fusions and exploited to illuminate features of nAChRs. The aim of this work was to create a ...
ascopubs.org

Nicotinic Acetylcholine Receptor Polymorphism, Smoking Behavior, and Tobacco-Related Cancer and Lung and Cardiovascular Diseases: A Cohort Study

Biomarker Analyses and Final Overall Survival Results From a Phase III, Randomized, Open-Label, First-Line Study of Gefitinib Versus Carboplatin/Paclitaxel in ...
News Medical

Molecular insights on the possible connection of SARS-CoV-2 and nicotinic acetylcholine receptors

A recent study posted to the bioRxiv* preprint server assessed the mechanism by which severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) Omicron and Alpha variants of concern (VOCs) inhibit ...
ALZFORUM

New Kid on the Block: Nicotinic Receptor Sensitive to Aβ

There’s a new player in town or, to be precise, in the rat brain. Based on a report in yesterday’s Journal of Neuroscience, scientists can now add the α7β2 heteromeric nicotinic acetylcholine receptor ...
JSTOR Daily

Nicotinic Acetylcholine Receptor β2 Subunits in the Medial Prefrontal Cortex Control Attention

This is a preview. Log in through your library . Abstract More than one-third of all people are estimated to experience mild to severe cognitive impairment as they age. Acetylcholine (ACh) levels in ...
ALZFORUM

Nicotinic Knockouts Reveal Role of Aβ Receptor in AD Mice

The α7 nicotinic acetylcholine receptor (α7nAChR) binds the amyloid-β peptide (Aβ) with high affinity (Wang et al., 2000), and has been implicated in Aβ internalization, stimulation of tau ...
News Medical

Study refutes the nicotinic hypothesis of SARS-CoV-2 infection mechanism

Recent speculations propose that nicotinic acetylcholine receptors (AChRs) may serve as additional receptors for severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) to the host cells – also ...
Nasdaq

Bionomics Announces Update on the α7 Nicotinic Acetylcholine Receptor (nAChR) Positive Allosteric Modulator (PAM) Collaboration with MSD

ADELAIDE, Australia, and CAMBRIDGE, Mass., Sept. 14, 2023 (GLOBE NEWSWIRE) -- Bionomics Limited (Nasdaq: BNOX) (Bionomics or Company), a clinical-stage biotechnology company developing novel, first-in ...
EurekAlert!

Nicotinic receptor could be target for treatment of lung inflammation

It has been amply proven that smoking can cause serious diseases such as emphysema and cancer. A new study, however, shows that pharmacological stimulation of a specific type of nicotinic receptor in ...