Genes hold the recipe for proteins, which are made of amino acids. DNA only has four letters, or nucleotides, and each sequence of three nucleotide bases, or codon, encodes for one amino acid. There ...

Researchers are adding new evidence to the emerging concept that 'silent' or synonymous mutations may have crucial consequences. Their study showed how a synonymous mutation in one gene can ...

Occasionally, single-letter misspellings in the genetic code, known as point mutations, occur. Point mutations that alter the resulting protein sequences are called nonsynonymous mutations, while ...

DNA has to be interpreted by cells. The letters or bases that make up genetic sequences are read in sets of three, and those three-base sequences are known as codons. Every codon encodes for one amino ...

Hypertension is a cardiovascular disease that seriously threatens global public health. Early and effective control of blood pressure can prevent the occurrence of target organ damage and ...

A central assumption about so-called synonymous mutations, which are changes in the coding sequence of proteins that do not lead to changes in its amino acid sequence, is being questioned by a study ...

For decades, researchers have viewed synonymous mutations as inconsequential quirks of the genome. Due to the way the genetic code is set up—where multiple three-base-pair codons can encode the same ...

Human eggs appear to be protected against a certain type of age-related mutation. In a small study, researchers found no signs that mutations accumulate in the mitochondrial DNA of human egg cells as ...

Congenital erythropoietic porphyria (CEP) or Günther’s disease is an inborn error of heme biosynthesis transmitted as an autosomal recessive trait and ...

Cystic fibrosis (CF) is an autosomal recessive disease due to a deleterious mutation in a chloride channel gene (CFTR = CF transmembrane conductance regulator), located on chromosome 7. From a ...

Point mutations that alter the resulting protein sequences are called nonsynonymous mutations, while those that do not alter protein sequences are called silent or synonymous mutations. Between ...