The attachment of sister kinetochores to microtubules from opposite spindle poles is necessary for accurate chromosome segregation during cell division. Unattached kinetochores activate the cell-cycle ...

This is a preview. Log in through your library . Abstract The specificity of the staining of CREST scleroderma patient serum was investigated by immunofluorescence and immunoelectron microscopy. The ...

In human cells, lengthy strands of DNA have to be carefully organized and compacted so they'll fit into the nucleus; our genome is arranged into chromosomes that have to be duplicated each time a cell ...

Which end of the kinetochore fibre shortens and whether shortening actively drives or passively permits polewards chromosome movement represent enduring problems in understanding anaphase ...

(Phys.org) -- With the first-ever three-dimensional image of an isolated kinetochore – the bulky molecular machine that connects a chromosome to the long, thin microtubules that tug it to one end of a ...

Cell division builds our bodies, supplying all cells in our tissues and organs, from the skin to the intestine, from the blood to the brain. It not only allows these organs to grow, but also to ...

Thousands of our cells successfully divide every day. They replicate their DNA and then separate so that each of the new cells has the same complement of chromosomes. If the process goes wrong and ...

Multiple asters (MAST)/Orbit is a member of a new family of nonmotor microtubule-associated proteins that has been previously shown to be required for the organization of the mitotic spindle. Here we ...

Osaka, Japan – During cell division, chromosomes, i.e., molecules containing our genetic material, must be properly replicated and segregated so that each daughter cell receives a complete and ...

FINDINGS: Whitehead Institute scientists report that two proteins once thought to have only supporting roles, are the true "stars" of the kinetochore assembly process in human cells. RELEVANCE: The ...

Centromeres are visible under the microscope as constrictions in the chromosomes. During cell division, the kinetochore, which is attached to the centromere, adheres to the microtubuli of the ...

Crowning a quest into a very well-guarded secret: Structure of the kinetochore corona finally revealed Date: April 8, 2022 Source: Max Planck Institute of Molecular Physiology Summary: During cell ...