The dentate gyrus (DG) is a region of the mammalian brain known to support the encoding of new memories. This brain region is part of the hippocampal formation, a set of brain regions involved in ...

Neuroscientists have located the cells that help reprogram long-lasting memories of traumatic experiences towards safety, a first in neuroscience. Memories of traumatic experiences can lead to mental ...

In a paper recently published in PNAS Nexus, researchers from the Department of Comparative Biosciences at the University of Illinois Urbana-Champaign describe how they were able to inhibit the ...

The dentate gyrus is distinct from the entorhinal cortex, the hippocampal region affected in early-stage Alzheimer's disease. Previous work, including by the laboratory of senior author Scott A. Small ...

Newborn granule cells show high excitability that disappears as the cells mature. Little has been known about the mechanisms that create low excitability in mature cells or how excitability of the ...

Age-related memory decline and neurodegenerative diseases like Alzheimer's are often thought of as irreversible. But the brain is not static; neurons continually adjust the strength of their ...

ONE OF THE first signs of Alzheimer’s disease is confusion. Most people can park their car in a different space every morning and find it again in the evening. Those with Alzheimer’s find this type of ...

Few would challenge the notion that a physically active life is better for the body, including the brain, than one spent parked on the couch. Exercise also reportedly sharpens the mind and fends off ...

Despite doubts last year about human adult neurogenesis, a study shows even 80-year-olds develop new cells in the hippocampus, but such growth is diminished in patients with Alzheimer’s disease. A ...