The factors involved in the removal of RNA primers during plastid DNA (ptDNA) replication have been unclear. We now identify a plastid-localized 5′–3′ exonuclease (PEN1) that mediates the removal of ...

Efficient and accurate DNA replication is essential for the preservation and transmission of the genetic information of all living organisms, from bacteria to humans. However, DNA replication shares ...

If you are anything like us, whenever you plan a journey, you spend a remarkable amount of time thinking about the start and ...

"DNA guides are far cheaper and easier to manufacture than RNA guides, and they are far more stable," Jain said. "While RNA molecules degrade quickly, DNA can remain intact for long periods." Together ...

A DNA-guided CRISPR platform could make RNA detection and control more stable, scalable, and precise, opening new routes for diagnostics, transcriptome engineering, and future therapeutic research.

DNA and RNA methylation, initially thought to operate as distinct pathways, have been shown to interact closely, shifting our understanding of gene regulation. A team of researchers from the ...

Chemists at UCL and the MRC Laboratory of Molecular Biology have demonstrated how RNA (ribonucleic acid) might have replicated itself on early Earth—a key process in the origin of life. Scientists ...

Insights could not only pave the way for new treatment strategies for genetic disorders, cancer and neurodegenerative diseases, but also enhance gene-editing technologies.

CRISPR’s rise from obscure bacterial defense system to molecular scalpel has always hinged on one small component: the guide RNA. For years, that guide RNA—meticulously designed, modified, and ...

Caltech researchers have identified a novel chemical reaction that could explain the formation of the building blocks of DNA ...

Your DNA is continually damaged by sources both inside and outside your body. One especially severe form of damage called a double-strand break involves the severing of both strands of the DNA double ...