DNA replication and repair mechanisms constitute the foundation of genomic integrity, ensuring that genetic information is faithfully duplicated and maintained across cell generations. Replication ...

Before a cell divides, its DNA is replicated so that each daughter cell inherits the same genetic information. The two copies, known as "sister chromatids," are held together by a ring-shaped protein ...

Eukaryotic DNA replication is initiated at multiple origins through a tightly regulated sequence of events: origin licensing, helicase activation and assembly of the replisome. The replicative ...