The presence of DNA in the cytoplasm of mammalian cells is a danger signal that triggers host immune responses such as the production of type I interferons. Cytosolic DNA induces interferons through ...

Cyclic adenosine monophosphate (cAMP) is a ubiquitous second messenger that underpins a wide array of physiological processes. It activates multiple effector pathways, most notably protein kinase A ...

Investigators from Mass General Brigham have developed a way to promote antitumor immunity by hijacking cellular machinery within cancer cells.

Data cleaning and analysis were performed using PLINK software. 53 Samples missing >2% of their genotypes were excluded because missingness can be indicative of low ...

The well-known second messenger cyclic adenosine 3′-5′-monophosphate (cAMP) plays a central role in the cells response to external stimuli. While the regulation of cAMP can be controlled by a number ...

Investigators from Mass General Brigham have developed a way to promote antitumor immunity by hijacking cellular machinery within cancer cells. The study demonstrated that inducing cancer cells to ...

This is a preview. Log in through your library . Abstract Inherited and somatic mutations in the adenomatous polyposis coli occur in most colon cancers, leading to activation of β-catenin-responsive ...

The brain on drugs Drugs elevate CREB activity in the nucleus accumbens by activating cyclic AMP pathway, causing protein kinase A to translocate to the nucleus and phosphorylate CREB. Target genes ...

Specific variations or mutations in a particular can gene raise a man's risk of familial, or inherited, testicular germ-cell cancer, the most common form of this disease, according to new research.

Tumors were eradicated in 30% of mice receiving cGAS LNPs injected into the tumor, in combination with immune checkpoint blockade.

Specific variations or mutations in a particular can gene raise a man's risk of familial, or inherited, testicular germ-cell cancer, the most common form of this disease, according to new research by ...